i should be writing
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you can download entire libgen archive if you are so inclined, there’s even torrents list https://libgen.rs/repository_torrent/
i think that it’s mostly because they don’t want somebody with 0 shared files to download - and i sorta understand that, would be lot cooler if people weren’t leeches only, sure, but i can’t be bothered to check or enforce. if you have something shared and message them they’ll usually allow to download
i’ve noticed that LW replaces what i assume are some slurs in comments with removed it’s automated, there’s no indication that content was edited, nobody announced that, nothing appears in modlog so it must be done in db directly
that and they also prohibit use of vpns and tor
they also took suspiciously long to defederate exploding heads, compared to some leftist instance that i don’t remember now but that instance wasn’t an issue
one of these aminoacids has a rather fancy linker attached to another two aminoacids, getting this to work was probably the hardest part of development of this compound. once you have structure it’s a solved problem, esp with peptide coupling chemistry, it can be literally printed on solid substrate residue by residue (humans make it cheaper, greener and on larger scale tho)
.se worked last time i’ve checked
arxiv has a narrow scope, there’s also biorxiv.org but both are for preprints which is a little bit different thing
sci-hub.se will get you most of papers
libgen.rs will get you most of books
you absolutely can lol
AbsolutelyNotCats is (probably) talking about some of not-yet-banned compounds predicted to have some recreational properties, sold as a “research chemicals” because these are not and will be not tested. people like DMT or 2C-B? slap a methyl here or hydroxyl there and you’re good to go with selling this because it’s not illegal to do so. you can’t call this thing as safe or pharmaceutical or anything else, because it’s not tested this way
there are also CROs that will make a panel of compounds of your choice that you then test in some high-throughput screening and these are legit, non-sketchy companies that do participate in pharmaceutical design. that’s entirely different thing
i don’t think so, if the model is owned by single company, trained on their own dataset, access is restricted and basically used as an internal tool, that would make that company sole owners of all generated content right? that’s what happened with chematica, this is used for synthesis planning at merck so mildly similar area
i hate to be the one that tells you this, but some rando cooking tryptamines in garage is not the kind of “research chemicals” that legit drug research uses. these are called CRO, contract research organizations and that would be Enamine ltd most of the time, they can make a wide array of compounds on demand. legit labs can get whatever they need (with appropriate paperwork), either as material for in vivo/in vitro testing or analytical standard
sometimes people get paid for participating in phase 1 trials, not the other way around
this thing was rediscovered four years ago and no trial was done? gee i wonder why
Experts applaud the computational approach, but say these compounds are not likely to be the drugs we need
The results show “how much can be achieved when skilled practitioners and machine-learning teams work together,” says Günter Klambauer, who leads an AI drug-discovery lab
Antibiotics experts also praised the group’s methods but were unimpressed by halicin. Several said the group’s results did not suggest the compound is the kind of antibiotic doctors need
the algorithm was too limited and didn’t allow the program to find truly novel structures: “We need new antibacterial chemotypes that may be hard to find through this approach,” says Richard E. Lee, an antibiotics researcher at St. Jude Children’s Research Hospital. And nitroaromatic groups can be toxic to human patients, as can the membrane-associated mechanism of action the researchers describe, says Shahriar Mobashery, a biochemist at the University of Notre Dame.
Collins says it’s fair to point out their molecules’ similarities to existing antibiotics. But he stresses that one of the major values in using machine learning is its speed in searching for antibiotic-like molecules. It took their model about 4 days to evaluate more than 100 million molecules.
(J. J. Collins is corresponding author of the paper cited) it’s garbage, but that garbage was generated fast!
John H. Rex, chief medical officer at the drug discovery firm F2G, echoed that critique. Rex, a former editor of the journal Antimicrobial Agents and Chemotherapy, says the work did not meet his standards for announcing a new antibiotic drug lead. In addition to his concerns about its efficacy against the most dangerous bacteria, Rex said the group’s tests of halicin’s toxicity fell short. He says he’d like to have seen the researchers test its toxicity against mammalian cells, which could provide a clearer picture of whether halicin would be toxic in the human bloodstream.
“It is quite easy to kill bacteria, even the tough ones, with toxic agents—and quite easy to find those,” says antibiotic expert Lynn Silver, who worked at Merck & Co. for 2 decades. But she says finding drugs is much harder: “Even well studied antibacterials fail in clinical trials due to toxicity.”
my policy of keeping techbros out of wet lab is unchanged
soo, they trained AI on some set of compounds, then AI combed through them and found an old failed diabetes drug, and it seems to be killing some bacteria, via mechanism that involves binding to metals, which is notoriously nonselective, with no comment on how toxic can it be, incl that failed diabetes-influencing activity
i remain sceptical on this one
you bet they are, it took them a month to “communicate” and “decide with community” to defed exploding heads, allowing them to grow 3x in the meantime, entire week for rammy site, but hexbear, a much larger instance that wasn’t caught proselytizing outside, got defederated “preemptively”. what the fuck is this bullshit?
they do have pretty strong biases, but i’m guessing they got caught in their own circlejerk that tells them that all of that is normal. just look at any pinned post on .world and go into comments
govt of mali let use freenom .ml domains, then freenom removed them for reasons, one of reasons being that it got traction. (?) they have moved since to fmhy.net
why would anyone willingly go to lebanon. it’s a country with cold civil war, only marginally more stable than syria, perpetual shitshow since it was an independent country